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Lan Yin

Lan Yin is currently an Associate Professor at Tsinghua University. She received her Bachelor’s degree from Tsinghua University in 2007 and Ph.D. degree from Carnegie Mellon University in 2011, both in Materials Science and Engineering. She worked as a posdoctoral research associate in Massachusetts Institute of Technology in 2011-2012 and University of Illinois Urbana-Champaign in 2012-2015. In 2015, she joined School of Materials Science and Engineering at Tsinghua University with Young Scholar Award. She has received the Excellent Young Scholar Award from the National Natural Science Foundation of China (NSFC) and is honored with the Chinese Materials Research Society (CMRS) the first prize of Science and Technology Award. Her research interests are focused on biodegradable materials and electronics, including biodegradable batteries, sensors, and therapeutic devices.


Biodegradable materials for electronic medicine and biosensors 

Lan Yin*

* School of Materials Science and Engineering, Tsinghua University 100084 Beijing (lanyin@tsinghua.edu.cn)

Abstract

Biodegradable electronics are a new category of devices that can completely degrade in physiological environments, eliminating the need for secondary surgeries to retrieve the devices and minimizing the risks of associated infections. These devices could play a critical role in various therapeutic and diagnostic processes, including promoting tissue regeneration, modulating neural activities, probing critical biomarkers, etc. Here, we propose a fully biodegradable and self-electrified conduit device for sciatic nerve regeneration, which enables successful nerve regrowth and motor function restoration in rodents. Electrolytic nitric oxide production is accomplished based on fully degradable Zn batteries, to modulate the behavior of cellular network. Furthermore, real-time detection of nitric oxide in biological systems, based on degradable materials integrating wireless modules, has been realized, which offers essential information for monitoring inflammatory responses. Overall, these works can open new avenues in the field of biodegradable electronics, offering immense potential for future healthcare application.