Login Sign Up

Mengdi Han

Dr. Mengdi Han is an Assistant Professor in the Department of Biomedical Engineering, College of Future Technology, Peking University. He received his B.S. degree in Huazhong University of Science and Technology in 2012 and Ph.D. degree in Peking University in 2017. He was a visiting Ph.D. student at Department of Materials Science and Engineering, University of Illinois Urbana-Champaign from 2015 to 2017. He worked as a postdoctoral fellow at Querrey Simpson Institute for Bioelectronics, Northwestern University from 2017 to 2020. He published more than 100 SCI-indexed papers, including Nature Electronics, Nature Biomedical Engineering, Science Translational Medicine, Science Robotics, Proceedings of the National Academy of Sciences, Advanced Materials, etc. His research group aims to develop and build bioelectronics with 3D architectures. The resulting 3D bioelectronics can form conformal interfaces with soft, curvilinear biological tissues, and enable new modalities in diagnosis and therapy.


Millimeter-scale implants for wireless biosensing

Ji Wan, Zhongyi Nie, Mengdi Han

Department of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China (hmd@pku.edu.cn)

Abstract

Implantable sensors can directly interface with various organs for precise evaluation of health status[1-5]. However, extracting signals from such sensors must rely on transcutaneous wires, integrated circuit chips, or cumbersome readout equipment, which increases the risks of infection, reduces the biocompatibility, or limits the portability. Here, we develop a set of millimeter-scale, chip-less and battery-less implants that can measure biophysical and biochemical signals wirelessly. In particular, the implants form two-way communications with a fully integrated wearable device, where the wearable deivce can induce a damped vibration of the implants and capture their subsequent motions in a wireless manner. Such damped vibrations reflect not only the biophysical conditions surrounding the implants movements, but also the concentration of a specific biochemical depending on the surface modification. Experiments in rat models demonstrate the capabilities in measuring cerebrospinal fluid (CSF) viscosity, intracranial pressure (ICP), and CSF glucose levels. This miniaturized system opens possibility for continuous, wireless monitoring of a wide range of biophysical and biochemical conditions within the living organism.

 

References

[1] Feiner, R.; Dvir, T.: Tissue–electronics interfaces: from implantable devices to engineered tissues. Nature Reviews Materials, Vol. 3, pp. 17076, 2017.

[2] Yacoub, M. H.; McLeod, C.: The expanding role of implantable devices to monitor heart failure and pulmonary hypertension. Nature Reviews Cardiology, Vol. 15, pp. 770-779, 2018.

[3] Bai, W. et al.: Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity. Nature Biomedical Engineering, Vol. 3, pp. 644-654, 2019.

[4] Abraham, W. T. et al.: Sustained efficacy of pulmonary artery pressure to guide adjustment of chronic heart failure therapy: complete follow-up results from the CHAMPION randomised trial. Lancet, Vol. 387, pp. 453-461, 2016.

[5] Garg, S. K. et al.: Evaluation of accuracy and safety of the next-generation up to 180-day long-term implantable Eversense continuous glucose monitoring system: the PROMISE study. Diabetes Technology & Therapeutics, Vol. 24, pp. 84-92, 2022.